Morel Anne-Pierre, Lièvre Marjory, Thomas Clémence, Hinkal George, Ansieau Stéphane, Puisieux Alain
Centre Léon Bérard, Lyon, France.
PLoS One. 2008 Aug 6;3(8):e2888. doi: 10.1371/journal.pone.0002888.
Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
最近，癌症生物学领域出现了两个新的概念：所谓“癌症干细胞”在肿瘤起始中的作用，以及上皮-间质转化（EMT）在上皮癌细胞转移扩散中的参与。利用乳腺肿瘤进展模型，我们发现，在Ras-MAPK信号通路激活后，具有“癌症干细胞”的干性和致瘤特性的细胞可从人乳腺上皮细胞衍生而来。这些干性和致瘤特性的获得是由EMT诱导驱动的。
