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PPAR-α、PPAR-γ和RXR的激动剂可抑制炎症小鼠体内巨噬细胞形成泡沫细胞。

Agonists of PPAR-alpha, PPAR-gamma, and RXR inhibit the formation of foam cells from macrophages in mice with inflammation.

作者信息

Dushkin M I, Khoshchenko O M, Posokhova E N, Schvarts Y Sh

机构信息

Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.

出版信息

Bull Exp Biol Med. 2007 Nov;144(5):713-6. doi: 10.1007/s10517-007-0413-3.

Abstract

We studied the effect of agonists of peroxisome proliferator-activated receptors alpha and gamma and retinoid X receptors on the concentration and synthesis of lipids in macrophages of C57B1/6 mice with inflammation induced by intraperitoneal injection of zymosan. We revealed a significant increase in [1-14C]oleate incorporation into cholesterol esters and triglycerides, increase in the content of free cholesterol, cholesterol esters, and triglycerides, and formation of oil red-stained lipid inclusions in peritoneal macrophages 24 h after administration of zymosan in a dose of 50 mg/kg. Treatment with agonists of retinoid X receptors and peroxisome proliferator-activated receptors alpha and gamma 30 min before and 12 h after zymosan injection decreased the synthesis of triglycerides and cholesterol esters, reduced the content of free cholesterol, cholesterol esters, and triglycerides in macrophages, and prevented the formation of cytoplasmic lipid inclusions in macrophage-derived foam cells during inflammation.

摘要

我们研究了过氧化物酶体增殖物激活受体α和γ以及视黄酸X受体的激动剂对腹腔注射酵母聚糖诱导炎症的C57B1/6小鼠巨噬细胞中脂质浓度和合成的影响。我们发现,在以50mg/kg的剂量给予酵母聚糖24小时后,[1-14C]油酸掺入胆固醇酯和甘油三酯的量显著增加,游离胆固醇、胆固醇酯和甘油三酯的含量增加,并且腹膜巨噬细胞中出现油红染色的脂质包涵体。在注射酵母聚糖前30分钟和注射后12小时用视黄酸X受体以及过氧化物酶体增殖物激活受体α和γ的激动剂进行处理,可减少甘油三酯和胆固醇酯合成,降低巨噬细胞中游离胆固醇、胆固醇酯和甘油三酯的含量,并防止炎症期间巨噬细胞源性泡沫细胞中细胞质脂质包涵体的形成。

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