Wang Guang-Lu, Zhang Feng, Peng Xiao-Yan, Meng Shu-Min
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Zhonghua Yan Ke Za Zhi. 2008 Feb;44(2):152-6.
OBJECTIVE; To make a comparative study of the clinical characteristics and risk factors of nonischemic central retinal vein occlusion (CRVO) between patients younger and older than the age of 40.
It was a retrospective case series. Retrospective data analysis (including best corrected visual acuity, color fundus photograph and fundus fluorescein angiography, etc. ) was conducted in patients with nonischemic central retinal vein occlusion who were followed-up for 6 months or longer.
The data of 148 cases (151 eyes) were analyzed. The follow-up time was 6 months to 15 years, averaged 17 months. Among them, 39 patients (40 eyes) aged 40 years or younger, their age ranged from 15 to 40 years, averaged 27 years old. There were 20 cases of male patients (20 eyes) and accounted for 51% of total cases. The rest of the patients were above the age of 40 years old. Their age ranged from 41 to 76 years, averaged 57 years old. Male patients (53 cases, 54 eyes) accounted for 49% of total cases. In the younger patients, only 2 of them had a history of hypertension, no other systemic illness was found. In the older patients, more than 40% of them had a history of systemic illness, including hypertension and diabetes mellitus. Initial visual acuity showed no statistically significant difference between these two groups (Pearson, chi2 =0. 087, P = 0.769). There was a significant difference in final visual acuity between these two groups (Pearson, chi2 = 4.692, P = 0.047). Final visual acuity was 20/60 or better in 18 cases (45%) in the younger group, but only 25 cases (23%) in the older group. Final visual acuity was 20/200 or less in 67% of cases in the older group, while 35% in the younger group. Complications occurred more frequently in the older group. The difference of complication rate in these two groups was statistically significant (Pearson, chi = 8.763, P = 0.006). Final vision was statistically correlated with age, initial visual acuity and complications, but not with sex or systemic illness. CONCLUSIONS Systemic illness is a risk factor for the occurrence of CRVO in the older group, but not in the younger group. It does not affect the final visual acuity. Complications occurs less common in the younger group. Although final visual acuity was better in the younger group, but still 35% of them was 20/200 or less. Most of the patients in the older group have severe visual impairment. Active treatment should be given to both groups.
目的；比较年龄在40岁及以下和40岁以上的非缺血性视网膜中央静脉阻塞（CRVO）患者的临床特征和危险因素。
这是一项回顾性病例系列研究。对随访6个月或更长时间的非缺血性视网膜中央静脉阻塞患者进行回顾性数据分析（包括最佳矫正视力、彩色眼底照片和眼底荧光血管造影等）。
分析了148例（151只眼）的数据。随访时间为6个月至15年，平均17个月。其中，39例（40只眼）年龄在40岁及以下，年龄范围为15至40岁，平均27岁。男性患者20例（20只眼），占总病例的51%。其余患者年龄在40岁以上。年龄范围为41至76岁，平均57岁。男性患者53例（54只眼），占总病例的49%。在年轻患者中，只有2例有高血压病史，未发现其他全身性疾病。在老年患者中，超过40%有全身性疾病史，包括高血压和糖尿病。两组的初始视力无统计学显著差异（Pearson检验，卡方值=0.087，P=0.769）。两组的最终视力有显著差异（Pearson检验，卡方值=4.692，P=0.047）。年轻组18例（45%）最终视力达到20/60或更好，而老年组只有25例（23%）。老年组67%的病例最终视力为20/200或更低，而年轻组为35%。并发症在老年组中更频繁发生。两组并发症发生率的差异有统计学意义（Pearson检验，卡方值=8.763，P=0.006）。最终视力与年龄、初始视力和并发症有统计学相关性，但与性别或全身性疾病无关。结论全身性疾病是老年组发生CRVO的危险因素，但在年轻组中不是。它不影响最终视力。并发症在年轻组中较少见。虽然年轻组的最终视力较好，但仍有35%的患者为20/200或更低。老年组大多数患者有严重视力损害。两组均应积极治疗。
