Aoki I, Toyama K, Abe N, Yamamoto M, Ishikawa K
Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Exp Hematol. 1991 Sep;19(8):789-96.
Adenocarcinoma-755-bearing C57BL/6 mice developed anemia with the growth of the tumors. The numbers of granuloid and monocytoid progenitors (colony-forming unit in culture, CFU-C) of the bone marrow and spleen and the peripheral blood WBC counts increased in tumor-bearing mice. The erythroid progenitors (erythroid colony-forming units, CFU-E; erythroid burst-forming units, BFU-E) of the bone marrow showed a marked decrease, overcoming their increase in the spleen in tumor-bearing mice. Fractionation of conditioned medium of tumor cells led to the isolation of a protein of 80-kd molecular weight that stimulated murine CFU-C growth and inhibited the CFU-E and BFU-E growth in a dose-dependent manner. These results indicate that erythroid inhibitory factors produced by tumors exist in tumor-bearing mice. Erythroid inhibitory factors might also exist in non-hematological malignancies of humans, and they might be one of the mechanisms of anemia.
携带腺癌 - 755 的 C57BL/6 小鼠随着肿瘤生长出现贫血。荷瘤小鼠骨髓和脾脏中粒细胞和单核细胞祖细胞（培养中的集落形成单位，CFU - C）数量以及外周血白细胞计数增加。骨髓中的红系祖细胞（红系集落形成单位，CFU - E；红系爆式集落形成单位，BFU - E）显著减少，抵消了荷瘤小鼠脾脏中红系祖细胞的增加。肿瘤细胞条件培养基的分级分离导致分离出一种分子量为 80kd 的蛋白质，该蛋白质刺激小鼠 CFU - C 生长，并以剂量依赖方式抑制 CFU - E 和 BFU - E 生长。这些结果表明荷瘤小鼠体内存在肿瘤产生的红系抑制因子。红系抑制因子可能也存在于人类非血液系统恶性肿瘤中，并且它们可能是贫血的机制之一。
