[侧链末端片段氧化的甾醇的合成]

[Synthesis of sterols oxygenated in the terminal fragment of their side chains].

作者信息

Antonchik A V, Zhabinskiĭ V N, Khripach V A

出版信息

Bioorg Khim. 2008 Jul-Aug;34(4):437-50.

Abstract

Methods of stereoselective synthesis of oxysterols are considered by the examples of (25R)-26-hydroxycholesterol, (24S)-24,25-epoxycholesterol, and (24S)-24-hydroxycholesterol containing functional groups in the terminal fragments of their side chains. Special attention is paid to the problems of construction of chiral centers C24 and C25.

摘要

通过（25R）-26-羟基胆固醇、（24S）-24,25-环氧胆固醇和（24S）-24-羟基胆固醇（其侧链末端片段含有官能团）的实例，探讨了氧甾醇的立体选择性合成方法。特别关注了手性中心C24和C25的构建问题。