针对抑郁症状不一致或一致的双胞胎进行候选区域连锁分析。
Candidate region linkage analysis in twins discordant or concordant for depression symptomatology.
作者信息
Christiansen L, Tan Q, Kruse T A, McGue M, Christensen K
机构信息
Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):581-4. doi: 10.1002/ajmg.b.30841.
Genetic risk factors contribute considerably to both clinical affective disorders and subsyndromal mood level. There is moreover evidence to suggest that the genetic basis of bipolar disorder and unipolar depression overlap to some extent, and several linkage analyses have suggested evidence for a common susceptibility locus in affective disorders on chromosome 12q24. In this study we investigated the chromosome 12 candidate region for linkage to the mean level of depression symptomatology, over a 10-year follow-up, using a highly informative sample of concordant and discordant twin pairs selected from 4,731 participants of the Longitudinal Study of Ageing Danish Twins. Our results showed suggestive evidence of linkage to this region with a peak LOD score of 1.91 for marker D12S1634 located at 148 cM, and thus indicates that the previously identified disease locus at 12q24 is also a general vulnerability locus affecting the normal range of mood.
遗传风险因素在临床情感障碍和亚综合征情绪水平中都起着相当大的作用。此外，有证据表明双相情感障碍和单相抑郁症的遗传基础在一定程度上重叠，并且多项连锁分析表明在12号染色体q24区域存在情感障碍的共同易感性位点的证据。在本研究中，我们使用从丹麦双胞胎老龄化纵向研究的4731名参与者中选取的高度信息丰富的同卵和异卵双胞胎对样本，在10年的随访中调查了12号染色体上与抑郁症状平均水平相关的候选区域。我们的结果显示了与该区域存在连锁的提示性证据，位于148厘摩（cM）的标记D12S1634的最高对数优势（LOD）得分为1.91，因此表明先前在12q24处确定的疾病位点也是影响正常情绪范围的一般易感性位点。
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