（+）-异弗瑞格醇的从头合成
De novo synthesis of (+)-isofregenedol.
作者信息
Riou Maxime, Barriault Louis
机构信息
Department of Chemistry, 10 Marie Curie, University of Ottawa, Ottawa, Canada K1N 6N5.
出版信息
J Org Chem. 2008 Sep 19;73(18):7436-9. doi: 10.1021/jo801365z. Epub 2008 Aug 13.
PMID:18698826
Abstract
An efficient enantioselective synthesis of (+)-isofregenedol was achieved in 13 steps from commercially available cyclohexene oxide without the use of protecting groups. The tetrahydronaphthalenic core of isofregenedol was obtained via a gold(I)-catalyzed benzannulation recently developed in our laboratory.
摘要
从市售的环氧环己烷出发，无需使用保护基团，经13步反应实现了(+)-异弗瑞格多醇的高效对映选择性合成。异弗瑞格多醇的四氢萘核心是通过我们实验室最近开发的金(I)催化的苯并环化反应得到的。
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