Saito Yuichiro, Nakamura Tetsuya, Kurabayashi Masahiko
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine.
Nihon Rinsho. 2008 Aug;66(8):1525-9.
Reactive oxygen species (ROS) play a crucial role in development of hypertension. An increase in production of superoxide anion and hydrogen peroxide, reduction of nitric oxide synthesis, and a decrease in bioavailability of antioxidants have been demonstrated in human hypertension. Oxidative stress resulted in vascular injury, renal dysfunction, and hypertensive end-organ damage. However, recent clinical trials failed to show cardiovascular benefits of antioxidants. Furthermore, none of the large clinical trials were designed to demonstrate effects of specific antioxidants on blood pressure and development of mild hypertension. Research of ROS, oxidative stress, redox signaling, and hypertension is more important than ever. The role of oxidative stress in the development of mild hypertension will need to be undertaken.
活性氧（ROS）在高血压的发展中起着至关重要的作用。在人类高血压中，已证实超氧阴离子和过氧化氢的产生增加、一氧化氮合成减少以及抗氧化剂的生物利用度降低。氧化应激导致血管损伤、肾功能障碍和高血压靶器官损害。然而，最近的临床试验未能显示抗氧化剂对心血管有益。此外，没有一项大型临床试验旨在证明特定抗氧化剂对血压和轻度高血压发展的影响。对ROS、氧化应激、氧化还原信号传导和高血压的研究比以往任何时候都更加重要。需要研究氧化应激在轻度高血压发展中的作用。
