Wilberg Theresa, Hummelen Benjamin, Pedersen Geir, Karterud Sigmund
Department for Research and Education, Psychiatric Division, Ullevål University Hospital, 0407 Oslo, Norway.
Compr Psychiatry. 2008 Sep-Oct;49(5):460-8. doi: 10.1016/j.comppsych.2007.12.008. Epub 2008 Mar 21.
Personality disorder not otherwise specified (PD NOS) is a frequently applied diagnosis, but we lack knowledge of the clinical appearance of patients receiving the diagnosis. This study applied a large clinical sample (N = 1516) to investigate (1) the prevalence and diagnostic and clinical characteristics of patients with PD NOS defined according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and (2) the prevalence and psychosocial impairment associated with different definitions of PD NOS.
Patients from the Norwegian Network of Psychotherapeutic Day Hospitals diagnosed in accordance with the LEAD standard (Longitudinal, Expert, All Data) were evaluated on several clinical measures at admission and discharge from short-term treatment.
The DSM-IV PD NOS category was the third most frequent PD diagnosis. Seventeen percent of the total sample and 22% of those with PDs had a PD NOS diagnosis, with an average of 9 PD criteria. Patients with PD NOS were heterogeneous with respect to types of PD criteria, 41% were not subthreshold on any specific PD. The PD NOS patients were intermediate between patients with specific PDs and those with no PD regarding number of fulfilled PD criteria and several social and clinical variables. Alternative operationalizations of PD NOS, that is, subthreshold on at least 2 specific PDs or meeting a minimum of 10 PD criteria, resulted in lower prevalence rates and defined clinically more impaired patients.
The PD NOS defined according to DSM-IV has a high prevalence and seems to capture a group of patients with fewer PD criteria and less severe psychosocial impairment compared to patients with specific PDs. The findings indicate that the operational definition of PD NOS may have a strong impact on the prevalence and clinical appearance of patient receiving this diagnosis.
未特定的人格障碍(PD NOS)是一种常用的诊断,但我们对接受该诊断的患者的临床表现缺乏了解。本研究采用了一个大型临床样本(N = 1516)来调查:(1)根据《精神疾病诊断与统计手册》(DSM-IV)定义的PD NOS患者的患病率、诊断和临床特征;(2)与不同PD NOS定义相关的患病率和社会心理损害。
来自挪威心理治疗日间医院网络的患者按照LEAD标准(纵向、专家、所有数据)进行诊断,并在短期治疗入院和出院时接受多项临床测量评估。
DSM-IV的PD NOS类别是第三常见的人格障碍诊断。总样本的17%以及人格障碍患者中的22%被诊断为PD NOS,平均有9条人格障碍标准。PD NOS患者在人格障碍标准类型方面具有异质性,41%在任何特定人格障碍上都未达到阈下水平。在满足的人格障碍标准数量以及一些社会和临床变量方面,PD NOS患者介于特定人格障碍患者和无人格障碍患者之间。PD NOS的替代操作定义,即至少在2种特定人格障碍上达到阈下水平或满足至少10条人格障碍标准,导致患病率较低,并定义了临床上受损更严重的患者。
根据DSM-IV定义的PD NOS患病率较高,与特定人格障碍患者相比,似乎涵盖了一组人格障碍标准较少且社会心理损害较轻的患者。研究结果表明,PD NOS的操作定义可能对接受该诊断的患者的患病率和临床表现有很大影响。