近期初次感染的儿童中抗人疱疹病毒6型IgM检测的准确性

The accuracy of anti-human herpesvirus 6 IgM detection in children with recent primary infection.

作者信息

de Oliveira Vianna Renata Artimos, Siqueira Marilda Mendonça, Camacho Luiz Antonio Bastos, Setúbal Sérgio, Knowles Wendy, Brown David W, de Oliveira Solange Artimos

机构信息

Policlínica Comunitária do Largo da Batalha, Fundação Municipal de Saúde de Niterói, RJ, Brazil.

出版信息

J Virol Methods. 2008 Nov;153(2):273-5. doi: 10.1016/j.jviromet.2008.07.002. Epub 2008 Aug 29.

DOI:10.1016/j.jviromet.2008.07.002

PMID:18703091

Abstract

Human herpesvirus 6 (HHV-6) has been shown to infect almost all children by 4 years of age. Even with a typical clinical presentation, HHV-6 infection is misdiagnosed frequently as measles or rubella. The aim of this study was to assess the accuracy of the IgM test for detection of recent primary HHV-6 infection. The study was conducted between January, 1998 and December, 2006 at primary health care units in Niterói, Rio de Janeiro, Brazil. Sera from 185 children, in whom measles, rubella, dengue fever and parvovirus B19 infections were excluded, were studied for anti-HHV-6 IgG and IgM antibodies using an indirect immunofluorescence test. Seventy-one (38.4%) of the children had evidence of primary HHV-6 infection. Taking the IgG avidity test as the "gold standard", the following results for IgM were obtained-sensitivity: 76.1%; specificity: 87.5%; accuracy: 82.4%. This study confirmed the low accuracy of IgM detection for the diagnosis of primary HHV-6 infection.

摘要

人类疱疹病毒6型（HHV - 6）已被证明在4岁时几乎感染所有儿童。即使临床表现典型，HHV - 6感染也经常被误诊为麻疹或风疹。本研究的目的是评估IgM检测对近期原发性HHV - 6感染检测的准确性。该研究于1998年1月至2006年12月在巴西里约热内卢尼泰罗伊的初级卫生保健单位进行。对185名排除了麻疹、风疹、登革热和细小病毒B19感染的儿童血清，使用间接免疫荧光试验检测抗HHV - 6 IgG和IgM抗体。71名（38.4%）儿童有原发性HHV - 6感染的证据。以IgG亲和力试验作为“金标准”，IgM检测结果如下——敏感性：76.1%；特异性：87.5%；准确性：82.4%。本研究证实了IgM检测在原发性HHV - 6感染诊断中的低准确性。