First Department of Internal Medicine, Semmelweis University Budapest, Budapest, Hungary.
Osteoporos Int. 2009 Apr;20(4):639-45. doi: 10.1007/s00198-008-0709-9. Epub 2008 Aug 13.
LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density.
The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake.
We studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out.
Frequency of aversion to milk consumption was 20% for CC genotype and 10% for TT + TC genotypes (p = 0.03). The albumin-adjusted serum calcium was 2.325 +/- 0.09 mmol/L for CC genotype and 2.360 +/- 0.16 mmol/L for TT + TC genotypes (p = 0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105 +/- 1.42 vs 0.406 +/- 1.32; p = 0.038), at the total hip (-0.471 +/- 1.08 vs -0.170 +/- 1.09; p = 0.041), and at the Ward's triangle (-0.334 +/- 0.87 vs -0.123 +/- 0.82; p = 0.044).
LCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.
LCT 13910 CC 基因型与乳糖不耐受有关，这种情况常导致牛奶摄入量减少。研究发现，CC 基因型的女性血清钙水平降低，骨密度降低。
LCT 基因 13910 C/T 多态性的 CC 基因型与乳糖不耐受和低钙摄入有关。
我们研究了 595 名绝经后妇女，包括 267 名骨质疏松症患者、200 名骨量减少患者和 128 名健康对照者。进行基因分型、骨密度测定和实验室检查。
CC 基因型对牛奶的厌恶频率为 20%，TT+TC 基因型为 10%（p=0.03）。白蛋白校正后的血清钙浓度，CC 基因型为 2.325±0.09mmol/L，TT+TC 基因型为 2.360±0.16mmol/L（p=0.031）。CC 基因型的桡骨（0.105±1.42 与 0.406±1.32；p=0.038）、全髋（-0.471±1.08 与-0.170±1.09；p=0.041）和 Ward 三角区（-0.334±0.87 与-0.123±0.82；p=0.044）的骨密度（Z 评分）均低于 TT+TC 基因型。
LCT 13910 C/T 多态性与绝经后妇女血清钙水平降低和骨密度降低有关。
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