Alheid George F, McCrimmon Donald R
Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611-3008, USA.
Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):3-11. doi: 10.1016/j.resp.2008.07.014.
The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.
呼吸的化学神经解剖学最终必须涵盖在脑干呼吸回路中生理上已确定的所有不同神经元成分,以及它们在延髓和脑桥内明显聚集成的“区室”。脑干中这些功能上定义的呼吸区室是控制气道的颅运动神经元以及激活吸气和呼气泵肌的脊髓运动神经元的主要输入来源。本综述概述了构成脑干呼吸回路的主要区室的神经解剖学,并简要介绍了其组成呼吸神经元所使用的递质。