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呼吸的化学神经解剖学。

The chemical neuroanatomy of breathing.

作者信息

Alheid George F, McCrimmon Donald R

机构信息

Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611-3008, USA.

出版信息

Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):3-11. doi: 10.1016/j.resp.2008.07.014.

DOI:10.1016/j.resp.2008.07.014
PMID:18706532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2701569/
Abstract

The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.

摘要

呼吸的化学神经解剖学最终必须涵盖在脑干呼吸回路中生理上已确定的所有不同神经元成分,以及它们在延髓和脑桥内明显聚集成的“区室”。脑干中这些功能上定义的呼吸区室是控制气道的颅运动神经元以及激活吸气和呼气泵肌的脊髓运动神经元的主要输入来源。本综述概述了构成脑干呼吸回路的主要区室的神经解剖学,并简要介绍了其组成呼吸神经元所使用的递质。

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本文引用的文献

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Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):38-48. doi: 10.1016/j.resp.2008.05.011.
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Botzinger expiratory-augmenting neurons and the parafacial respiratory group.包钦格呼气增强神经元与面神经旁呼吸组
J Neurosci. 2008 Mar 5;28(10):2506-15. doi: 10.1523/JNEUROSCI.5595-07.2008.
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A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.Phox2b基因的人类突变会导致二氧化碳化学感受性缺失、致命性中枢性呼吸暂停以及面神经旁核神经元的特异性缺失。
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1067-72. doi: 10.1073/pnas.0709115105. Epub 2008 Jan 15.
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Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism.5-羟色胺能神经元通过一种不依赖pH值的机制激活化学敏感的后包钦格复合体神经元。
J Neurosci. 2007 Dec 19;27(51):14128-38. doi: 10.1523/JNEUROSCI.4167-07.2007.
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Glutamatergic neurons in the Kölliker-Fuse nucleus project to the rostral ventral respiratory group and phrenic nucleus: a combined retrograde tracing and in situ hybridization study in the rat.结合逆行追踪和原位杂交技术对大鼠的研究: Kölliker-Fuse核中的谷氨酸能神经元投射至吻侧腹侧呼吸组和膈核
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