Yu Tian-Shui, Guan Da-Wei, Cheng Zi-Hui, Zhao Rui, Hu Geng-Yi, Zhu Rui-Xia, Wang Ling, Guo Xiao-Chong, Wang Chang-Liang
Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China.
Fa Yi Xue Za Zhi. 2008 Jun;24(3):168-71.
To establish a new animal model of grading skeletal muscle contusions that could be controllable and repetitive.
The rats' gastrocnemius was injured by a new weight-dropping device designed. The force acting on gastrocnemius with a comparatively constant duration and inducing elastic deformation of the gastrocnemius was expressed with velocity (v) and deformation (DF). Instant velocity was changed to create gastrocnemius contusions. Pathological changes of gastrocnemius were graded by the gross and histological examinations of 39 rats.
At low level of impact (v: 2 m/s, DF: 5.5 mm), mild injuries were detected in epimysium and superficial layer of gastrocnemius. At moderate level of impact (v: 2.5 m/s, DF: 6.5 mm), the injuries were observed in epimysium and whole gastrocnemius. At high level of impact (v: 3 m/s, DF: 7.5 mm), severe injuries were seen deeper to soleus with more extensive skeletal muscle damage.
Grading of skeletal muscle blunt force contusion is created by parameter of velocity and muscle deformation. The model could be used for further research on skeletal muscle contusions.
建立一种可控且可重复的骨骼肌挫伤分级动物新模型。
采用自行设计的新型重物坠落装置损伤大鼠腓肠肌。用速度（v）和形变量（DF）表示作用于腓肠肌且持续时间相对恒定并导致腓肠肌弹性形变的力。通过改变瞬时速度造成腓肠肌挫伤。对39只大鼠的腓肠肌进行大体和组织学检查，对腓肠肌的病理变化进行分级。
在低冲击水平（v：2 m/s，DF：5.5 mm）时，检测到肌外膜和腓肠肌浅层有轻度损伤。在中等冲击水平（v：2.5 m/s，DF：6.5 mm）时，肌外膜和整个腓肠肌均出现损伤。在高冲击水平（v：3 m/s，DF：7.5 mm）时，比目鱼肌深层出现严重损伤，骨骼肌损伤范围更广。
通过速度和肌肉形变量参数建立了骨骼肌钝性挫伤分级。该模型可用于骨骼肌挫伤的进一步研究。
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