用于提高免疫检测灵敏度的蛋白质纳米图案
Protein nanopatterns for improved immunodetection sensitivity.
作者信息
Valsesia A, Mannelli I, Colpo P, Bretagnol F, Rossi F
机构信息
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, 21020 Ispra (VA), Italy.
出版信息
Anal Chem. 2008 Oct 1;80(19):7336-40. doi: 10.1021/ac801021z. Epub 2008 Aug 19.
PMID:18710257
Abstract
In this work, we clearly demonstrate the capability of protein nanopatterns of improving the quality factors of immunosensing devices, such as lowering of the limit of detection and increase of sensitivity. This beneficial effect is obtained by the formation on the sensor's surface of bioadhesive domains of nanometric dimensions in a nonadhesive matrix by means of colloidal lithography.
摘要
在这项工作中，我们清楚地展示了蛋白质纳米图案改善免疫传感装置品质因数的能力，例如降低检测限和提高灵敏度。这种有益效果是通过胶体光刻技术在非粘附性基质中在传感器表面形成纳米尺寸的生物粘附域而获得的。
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