溶质在乙二醇水溶液中的溶解度预测
Solubility prediction of solutes in aqueous mixtures of ethylene glycols.
作者信息
Jouyban A, Soltanpour S, Tamizi E
机构信息
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Pharmazie. 2008 Jul;63(7):548-50.
PMID:18717495
Abstract
The applicability of a trained version of the Jouyban-Acree model, for predicting the solubility of solutes in aqueous mixtures of ethylene glycol and its polymerized forms was shown. The solubilities of 8 drugs in binary mixtures were determined and the mean percentage deviation (MPD) was calculated as a prediction accuracy criterion and the overall MPD (+/- SD) was 23.2 (+/- 13.1)%.
摘要
研究表明，训练后的Jouyban-Acree模型适用于预测溶质在乙二醇及其聚合形式的水性混合物中的溶解度。测定了8种药物在二元混合物中的溶解度，并计算了平均百分比偏差（MPD）作为预测准确性标准，总体MPD（±标准差）为23.2（±13.1）%。
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