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Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies.

作者信息

Jacobson-Kram D

机构信息

PhD, DABT, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (USA).

出版信息

Vet Pathol. 2008 Sep;45(5):707-9. doi: 10.1354/vp.45-5-707.

DOI:10.1354/vp.45-5-707

PMID:18725478

Abstract

摘要

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Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies.

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Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies.

Vet Pathol. 2008 Sep;45(5):707-9. doi: 10.1354/vp.45-5-707.

Putting chemicals on a path to better risk assessment.

Science. 2009 Aug 7;325(5941):694-5. doi: 10.1126/science.325_694.

Measurement and estimation of electrophilic reactivity for predictive toxicology.

Chem Rev. 2011 Apr 13;111(4):2562-96. doi: 10.1021/cr100098n. Epub 2011 Mar 14.

The Predict-IV project: Towards predictive toxicology using in vitro techniques.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):1-3. doi: 10.1016/j.tiv.2015.10.006.

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Toxicol In Vitro. 2011 Sep;25(6):1161. doi: 10.1016/j.tiv.2011.05.029. Epub 2011 Jun 12.

1.2 Aspects of test assessment.

Hum Exp Toxicol. 2009 Feb;28(2-3):95-6. doi: 10.1177/0960327109105757.

Toxicity testing gets a makeover.

Nature. 2009 Sep 10;461(7261):158. doi: 10.1038/461158a.

The value of the dog in long-term toxicity studies. The CMR international toxicology database.

Adverse Drug React Toxicol Rev. 1993 Spring;12(1):53-61.

Unbiased histological examinations in toxicological experiments (or, the informed leading the blinded examination).

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Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies.

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