脑转移绒癌成功治疗后的足月分娩：一例报告并文献复习

Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature.

作者信息

Behtash Nadereh, Behnamfar Fariba, Hamedi Bahareh, Ramezanzadeh Fatemeh

机构信息

Gynecology Oncology Department, Vali-e-Asr Hospital, Tehran University of Medical Sciences, 14194 Tehran, Iran.

出版信息

Arch Gynecol Obstet. 2009 Apr;279(4):579-81. doi: 10.1007/s00404-008-0753-x. Epub 2008 Aug 26.

DOI:10.1007/s00404-008-0753-x

PMID:18726607

Abstract

BACKGROUND

Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. Although gestational trophoblastic neoplasia has become the most curable of gynecological malignancies, failure rate among "high-risk" patients is still high despite of the use of aggressive multidrug regimens.

CASE

A 27-year-old woman (G(4)P(2)Ab(1)) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion. She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation. She delivered a term healthy child 2 years after termination of treatment.

CONCLUSION

Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.

摘要