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Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle.

作者信息

D'Ocon P, Blasco R, Candenas L, Ivorra D, López S, Villaverde C, Castedo L, Cortes D

机构信息

Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Universidad de Valencia, Spain.

出版信息

Eur J Pharmacol. 1991 Apr 17;196(2):183-7. doi: 10.1016/0014-2999(91)90426-q.

DOI:10.1016/0014-2999(91)90426-q
PMID:1874285
Abstract

The effects of nifedipine, papaverine and four benzylisoquinoline alkaloids (cularine, cularidine, celtisine and isocrasifoline) were studied in isolated rat uterus in order to clarify the mechanism of their relaxant action. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only papaverine acted intracellularly, promoting relaxation of contractile responses induced by oxytocin or vanadate in a Ca(2+)-free medium. In spite of the structural relationship between papaverine and the other alkaloids, the mechanism of their relaxant action is not the same. The activities of cularine derivatives and of isocrasifoline were similar to that of nifedipine.

摘要

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