硫酸葡聚糖与常压性缺氧对小鼠肠道隐窝干细胞的辐射防护作用
Radioprotective effect of dextran sulphate and aerogenic hypoxia on intestinal crypt stem cells in mice.
作者信息
Vacek A, Konoplyanikova O A, Konoplyanikov A G, Bartonícková A, Rotkovská D
机构信息
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
出版信息
Folia Biol (Praha). 1991;37(2):110-6.
PMID:1874338
Abstract
A single intraperitoneal injection of dextran sulphate given 6 h before irradiation produced higher numbers of microcolonies of intestinal crypt stem cells in whole-body irradiated mice than injection of saline in control mice. If dextran sulphate and hypoxia are combined, the radioprotective effect of hypoxia on intestinal crypt stem cells depends on the time interval between irradiation and administration of dextran sulphate.
摘要
在全身照射小鼠前6小时腹腔注射一次硫酸葡聚糖，与对照小鼠注射生理盐水相比，可产生更多数量的肠道隐窝干细胞微菌落。如果将硫酸葡聚糖与低氧联合使用，低氧对肠道隐窝干细胞的辐射防护作用取决于照射与硫酸葡聚糖给药之间的时间间隔。
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