肝内胆管癌患者手术治疗的影响及不良预后因素：60例患者的回顾性分析

The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients.

作者信息

Yamashita Yo-ichi, Taketomi Akinobu, Morita Kazutoyo, Fukuhara Takasuke, Ueda Shigeru, Sanefuji Kensaku, Iguchi Tomohiro, Kayashima Hiroto, Sugimachi Keishi, Maehara Yoshihiko

机构信息

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Anticancer Res. 2008 Jul-Aug;28(4C):2353-9.

DOI:

PMID:18751418

Abstract

BACKGROUND

Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC.

PATIENTS AND METHODS

Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses.

RESULTS

The overall survival rate of the R0 resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection.

CONCLUSION

R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended.

摘要