Shanmugam Victoria K, Steen Virginia D, Cupps Thomas R
Division of Rheumatology, Immunology and Allergy, Georgetown University Hospital, Washington, DC 20007, USA.
Isr Med Assoc J. 2008 Jul;10(7):534-6.
Lower extremity ulcers are a late complication of connective tissue diseases and occur more commonly in patients with these diseases than in the general population. Although these lesions have historically been attributed to vasculitis, it is now recognized that inflammatory vessel injury accounts for fewer than 20% of ulcers in connective tissue disease. The pathogenesis of these lesions is complex, and often several processes act synergistically to initiate and perpetuate tissue injury. We review the evidence for antiphospholipid antibodies and prothrombotic states contributing to a vasculopathy in patients with connective tissue disease, precipitating ulceration and impairing healing.
下肢溃疡是结缔组织病的晚期并发症，在患有这些疾病的患者中比在普通人群中更常见。尽管这些病变在历史上一直被归因于血管炎，但现在人们认识到，在结缔组织病中，炎症性血管损伤导致的溃疡不到20%。这些病变的发病机制很复杂，通常有几个过程协同作用，引发并持续组织损伤。我们综述了抗磷脂抗体和血栓前状态导致结缔组织病患者血管病变、引发溃疡和阻碍愈合的证据。
