肿瘤进展和转移中的类二十烷酸

Eicosanoids in tumor progression and metastasis.

作者信息

Krishnamoorthy Sriram, Honn Kenneth V

机构信息

Departments of Pathology, and Chemistry, Wayne State University School of Medicine, Detroit, MI 48202, USA.

出版信息

Subcell Biochem. 2008;49:145-68. doi: 10.1007/978-1-4020-8831-5_6.

DOI:10.1007/978-1-4020-8831-5_6

PMID:18751911

Abstract

Eicosanoids and the enzymes responsible for their generation in living systems are involved in the mediation of multiple physiological and pathophysiological responses. These bioactive metabolites are part of complex cascades that initiate and perpetuate several disease processes such as atherosclerosis, arthritis, neurodegenerative conditions, and cancer. The intricate role played by each of these metabolites in the initiation, progression, and metastasis of solid tumors has been a subject of intense research in the scientific community. This review summarizes some of the key aspects of eicasonoids and the associated enzymes, and the pathways they mediate in promoting tumor progression and metastasis.

摘要

类二十烷酸以及生物系统中负责其生成的酶参与多种生理和病理生理反应的调节。这些生物活性代谢产物是复杂级联反应的一部分，这些级联反应引发并维持多种疾病过程，如动脉粥样硬化、关节炎、神经退行性疾病和癌症。这些代谢产物中的每一种在实体瘤的起始、进展和转移中所起的复杂作用一直是科学界深入研究的课题。本综述总结了类二十烷酸和相关酶的一些关键方面，以及它们在促进肿瘤进展和转移中所介导的途径。