通过铜氢催化二芳基酮的硅氢化反应制备的非外消旋二芳基甲醇。
Nonracemic diarylmethanols from CuH-catalyzed hydrosilylation of diaryl ketones.
作者信息
Lee Ching-Tien, Lipshutz Bruce H
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
出版信息
Org Lett. 2008 Oct 2;10(19):4187-90. doi: 10.1021/ol801590j. Epub 2008 Aug 28.
PMID:18754623
Abstract
An efficient method for the synthesis of nonracemic diarylmethanols has been developed. The use of ( R)-(-)-(DTBM-SEGPHOS)CuH effects highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones.
摘要
已开发出一种合成非外消旋二芳基甲醇的有效方法。使用(R)-(-)-(DTBM-SEGPHOS)CuH可实现前手性二芳基酮的高度对映选择性1,2-硅氢化反应。
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