在少数儿童的良性皮肤病变中未检测到高危型人乳头瘤病毒（HPV）。
High-risk human papilloma viruses (HPVs) were not detected in the benign skin lesions of a small number of children.
作者信息
Mammas I, Sourvinos G, Michael C, Spandidos D A
机构信息
Department of Virology, School of Medicine, University of Crete, Crete, Greece.
出版信息
Acta Paediatr. 2008 Dec;97(12):1669-71. doi: 10.1111/j.1651-2227.2008.01004.x. Epub 2008 Aug 27.
AIM
Human papilloma virus (HPV) can be transmitted via sexual as well as nonsexual routes. Recently, 'high-risk' HPVs were detected in the oral mucosa of children in whose cases there was no suspicion of sexual abuse. This implies that HPV 16 and 18 have additional nonsexual modes of transmission in childhood, such as vertical transmission and autoinoculation.
METHODS
Using polymerase chain reaction (PCR) assays, we examined the skin tissues of 12 children with benign skin lesions, aged between 6 and 13 years, for the presence of HPV.
RESULTS
Among 12 biopsy skin specimens, no 'high-risk' HPV DNA was detected. Specific PCRs for HPV DNA 16 and 18 were also negative.
CONCLUSION
This preliminary case-control study indicates the absence of mucosal 'high-risk' HPV types in the benign skin lesions of children.
目的
人乳头瘤病毒（HPV）可通过性传播以及非性传播途径传播。最近，在未怀疑有性虐待情况的儿童口腔黏膜中检测到了“高危”HPV。这意味着HPV 16和18在儿童期有额外的非性传播方式，如垂直传播和自体接种。
方法
我们使用聚合酶链反应（PCR）检测法，检查了12名年龄在6至13岁之间患有良性皮肤病变的儿童的皮肤组织中是否存在HPV。
结果
在12份活检皮肤标本中，未检测到“高危”HPV DNA。针对HPV DNA 16和18的特异性PCR检测结果也为阴性。
结论
这项初步的病例对照研究表明，儿童良性皮肤病变中不存在黏膜“高危”HPV类型。
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