进餐对柠檬酸钾生理和物理化学作用的影响。

Effect of meal on the physiological and physicochemical actions of potassium citrate.

作者信息

Pak C Y, Oh M S, Baker S, Morris J S

机构信息

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75235.

出版信息

J Urol. 1991 Sep;146(3):803-5. doi: 10.1016/s0022-5347(17)37925-9.

DOI:10.1016/s0022-5347(17)37925-9

PMID:1875495

Abstract

The effect of meals on the physiological and physicochemical actions of potassium citrate was examined in 8 patients with nephrolithiasis maintained on a constant metabolic dietary regimen. Potassium citrate (20 mEq. 3 times per day), whether given with food or on an empty stomach, significantly increased urinary pH, citrate and potassium, and decreased urinary calcium and ammonium. Moreover, potassium citrate decreased urinary saturation of calcium oxalate and uric acid, although it slightly increased that of brushite. However, there was no significant difference in these measures when the drug was given with meals from the time when it was given on an empty stomach. Thus, the effect of potassium citrate on urinary risk factors is unaffected by food.

摘要

在8例维持恒定代谢饮食方案的肾结石患者中，研究了进餐对柠檬酸钾生理和物理化学作用的影响。柠檬酸钾（20毫当量，每日3次），无论与食物一起服用还是空腹服用，均能显著提高尿pH值、柠檬酸盐和钾含量，并降低尿钙和铵含量。此外，柠檬酸钾降低了草酸钙和尿酸的尿饱和度，尽管它略微提高了透钙磷石的尿饱和度。然而，与空腹服药相比，进餐时服药在这些指标上没有显著差异。因此，食物不影响柠檬酸钾对尿液危险因素的作用。