Naumanen P, Lappalainen P, Hotulainen P
Institute of Biotechnology, PO Box 56, 00014 University of Helsinki, Finland.
J Microsc. 2008 Sep;231(3):446-54. doi: 10.1111/j.1365-2818.2008.02057.x.
Stress fibres are contractile acto-myosin structures found from many types of non-muscle cells, where they are involved in adhesion, motility and morphogenesis. Stress fibres typically display a periodic alpha-actinin-myosin II pattern and are thus suggested to resemble the sarcomeric actin filament structures of muscle cells. Mammalian cells contain three categories of stress fibres: ventral stress fibres that are attached to focal adhesions at both ends, dorsal stress fibres that are attached to focal adhesions typically at one end and transverse arcs that are curved acto-myosin bundles, which do not directly attach to focal adhesions. In this review, we discuss the definition of stress fibres, organization of actin filaments and other components within these contractile structures, and the mechanisms of stress fibre assembly.
应力纤维是在多种非肌肉细胞中发现的收缩性肌动蛋白-肌球蛋白结构，它们参与细胞黏附、运动和形态发生。应力纤维通常呈现周期性的α-辅肌动蛋白-肌球蛋白II模式，因此被认为类似于肌肉细胞的肌节肌动蛋白丝结构。哺乳动物细胞包含三类应力纤维：两端附着于黏着斑的腹侧应力纤维、通常一端附着于黏着斑的背侧应力纤维以及弯曲的肌动蛋白-肌球蛋白束状的横向弧，横向弧不直接附着于黏着斑。在本综述中，我们讨论了应力纤维的定义、这些收缩结构内肌动蛋白丝和其他成分的组织以及应力纤维组装的机制。
