Tretter F, Albus M
Department of Addictions Isar Amper Clincis, Clinic Munich East, Munich, Germany.
Pharmacopsychiatry. 2008 Sep;41 Suppl 1:S2-S18. doi: 10.1055/s-2008-1081461.
Biological psychiatry has more and more directed it's focus on the involvement of genes and molecules in mental health and disease. On these levels, new approaches in other medical fields are noticed that are collectively dubbed "Systems Biology". Conceptually, this new paradigm tries to view molecular interactions in cellular networks as dynamic, self-organizing events that eventually result in an ordered maintenance of the whole system. A great deal of applied mathematics is required in systems biology to set up and carry out computer modeling and simulation. In terms of psychiatric research, developing "systems biology of the neuron" could become a pivotal achievement for a better understanding of mental illness on the molecular level. A brief outline of imminent tasks and links between systems biology and biological psychiatry is presented.
生物精神病学越来越将重点放在基因和分子在心理健康与疾病中的作用上。在这些层面上,人们注意到其他医学领域的新方法,这些方法被统称为“系统生物学”。从概念上讲,这种新范式试图将细胞网络中的分子相互作用视为动态的、自组织的事件,最终导致整个系统的有序维持。系统生物学需要大量应用数学来建立和进行计算机建模与模拟。就精神病学研究而言,发展“神经元系统生物学”可能成为在分子水平上更好地理解精神疾病的关键成就。本文简要概述了系统生物学与生物精神病学之间迫在眉睫的任务和联系。