Kiratisin Pattarachai, Sanmee Sittinee
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-Noi, Bangkok 10700, Thailand.
J Bacteriol. 2008 Nov;190(21):7291-7. doi: 10.1128/JB.00739-08. Epub 2008 Aug 29.
The Burkholderia pseudomallei quorum-sensing system (QSS), designated BpsIR, is encoded by five bpsR genes and three bpsI genes. This study investigated the roles and interactions of the QSS determinants in terms of gene regulation and protein interaction. We report two novel findings, that BpsR can function as an activator and a repressor for bpsI expression and that BpsR may form homodimers and heterodimers.
嗜麦芽窄食单胞菌群体感应系统(QSS),即BpsIR,由五个bpsR基因和三个bpsI基因编码。本研究从基因调控和蛋白质相互作用方面探究了QSS决定因素的作用及相互作用。我们报告了两个新发现,即BpsR可作为bpsI表达的激活剂和抑制剂,且BpsR可能形成同型二聚体和异型二聚体。