Price Jackie F, Stewart Marlene C, Deary Ian J, Murray Gordon D, Sandercock Peter, Butcher Isabella, Fowkes F Gerald R
Division of Community Health Sciences and Centre for Public Health and Primary Care Research, University of Edinburgh, Edinburgh.
BMJ. 2008 Sep 1;337:a1198. doi: 10.1136/bmj.a1198.
To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk.
Randomised double blind placebo controlled trial.
Central Scotland.
3350 men and women aged over 50 participating in the aspirin for asymptomatic atherosclerosis trial.
Low dose aspirin (100 mg daily) or placebo for five years.
Tests of memory, executive function, non-verbal reasoning, mental flexibility, and information processing five years after randomisation, with scores used to create a summary cognitive score (general factor).
At baseline, mean vocabulary scores (an indicator of previous cognitive ability) were similar in the aspirin (30.9, SD 4.7) and placebo (31.1, SD 4.7) groups. In the primary intention to treat analysis, there was no significant difference at follow-up between the groups in the proportion achieving over the median general factor cognitive score (32.7% and 34.8% respectively, odds ratio 0.91, 95% confidence interval 0.79 to 1.05, P=0.20) or in mean scores on the individual cognitive tests. There were also no significant differences in change in cognitive ability over the five years in a subset of 504 who underwent detailed cognitive testing at baseline.
Low dose aspirin does not affect cognitive function in middle aged to elderly people at increased cardiovascular risk.
ISRCTN 66587262.
确定低剂量阿司匹林对心血管风险中度升高的中老年男性和女性认知功能的影响。
随机双盲安慰剂对照试验。
苏格兰中部。
3350名年龄超过50岁的男性和女性，参与了无症状动脉粥样硬化的阿司匹林试验。
低剂量阿司匹林（每日100毫克）或安慰剂，为期五年。
随机分组五年后的记忆、执行功能、非语言推理、心理灵活性和信息处理测试，分数用于创建综合认知分数（一般因素）。
在基线时，阿司匹林组（30.9，标准差4.7）和安慰剂组（31.1，标准差4.7）的平均词汇分数（先前认知能力的指标）相似。在主要意向性分析中，随访时两组中达到综合认知分数中位数以上的比例（分别为32.7%和34.8%，优势比0.91，95%置信区间0.79至1.05，P = 0.20）或个体认知测试的平均分数没有显著差异。在基线时接受详细认知测试的504名亚组中，五年内认知能力的变化也没有显著差异。
低剂量阿司匹林对心血管风险升高的中老年人群的认知功能没有影响。
ISRCTN 66587262。
