Rolton H A, McConnell K M, Modi K S, Macdougall A I
Department of Biochemistry, Stobhill General Hospital, Glasgow, UK.
Nephrol Dial Transplant. 1991;6(6):440-3. doi: 10.1093/ndt/6.6.440.
Plasma oxalate was measured on two occasions in 18 patients with end-stage renal failure on regular haemodialysis treatment: once while on a routine dose of vitamin C (100 mg/day) and subsequently after 2 weeks administration of a larger dose of vitamin C (500 mg/day). Pre- and post-dialysis concentrations were all markedly increased, reflecting the reduced glomerular filtration rate of end-stage renal failure. Both pre- and post-dialysis oxalate increased significantly following the increase in ascorbate dose but there was no significant correlation between plasma oxalate and ascorbate results. Considerations governing dosage of vitamin C in patients with chronic renal failure are discussed.
对18例接受定期血液透析治疗的终末期肾衰竭患者在两个时间点测量了血浆草酸盐：一次是在常规剂量维生素C（100毫克/天）治疗期间，随后是在给予较大剂量维生素C（500毫克/天）2周后。透析前和透析后的浓度均显著升高，这反映了终末期肾衰竭患者肾小球滤过率降低。随着抗坏血酸剂量增加，透析前和透析后的草酸盐均显著升高，但血浆草酸盐与抗坏血酸结果之间无显著相关性。本文讨论了慢性肾衰竭患者维生素C剂量的相关影响因素。
