Zsoldos Tamás, Molnár Anna, Jánossy Agota, Kuncz Adám, Nagy Erno, Deák Gábor, Barzó Pál
Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Idegsebészeti Klinika, Szeged.
Ideggyogy Sz. 2008 Jul 30;61(7-8):244-9.
Cavernous angiomas comprise 5-10% of all vascular malformations in the central nervous system, occurring most frequently in the supratentorial region, and 20% of them in the brain stem. According to literature, brain stem cavernous angiomas occur most frequently in the pons (60%), and equally in the mesencephalon (20%) and in medulla oblongata. In clinical evaluation the authors describe the successful removal of a mesencephalic cavernous angioma causing progressive neurological deficits and symptoms. The authors present a case of a 51 year old female, who had developed 1 year prior to her admittance: fatigue, weakness in the right upper limb and fingers, right lower limb ataxia. One month later, her lower right limb developed sensory deficits. The first neurological exploration indicated dysarthria, moderate facial and right hemiparesis, hemihypaesthesia and ataxia. CT and MR imaging indicated multilobulated cavernomas in the mesencephalon. After conservative treatment the patient became almost symptom free, and thus neurosurgical treatment was not discussed. Later on her symptoms fluctuated, but after 6 month she suddenly developed progressive right hemiparesis, right facial weakness, serious dysphasia, and emotional incontinence combined with continuous spastic sobbings. The control MRI showed enlargement of the cavernomas and new extravasation. Surgery was indicated for removing the cavernomas. The left infratentorial, supracerebellar approach revealed a blood engorged cavernoma in the center of the mesencephalon, almost dividing it. The cavernomas and accompanying haematoma was extirpated. The patient's neurological symptoms rapidly improved after surgery, her dysphasia as well as motor weakness have disappeared. Six days after surgery, we discharged a neurologically symptomless and self-supporting patient. The literature and the presented case indicates that the correct timing and proper surgery allows brain stem cavernomas to be safely removed, or significantly bated, which results in the massive regression of neurological symptoms.
海绵状血管瘤占中枢神经系统所有血管畸形的5% - 10%,最常发生于幕上区域,其中20%位于脑干。根据文献,脑干海绵状血管瘤最常发生于脑桥(60%),中脑(20%)和延髓的发生率相同。在临床评估中,作者描述了成功切除一例导致进行性神经功能缺损和症状的中脑海绵状血管瘤。作者介绍了一名51岁女性的病例,她在入院前1年出现:疲劳、右上肢体和手指无力、右下肢共济失调。1个月后,她的右下肢出现感觉障碍。首次神经检查显示构音障碍、中度面部及右侧偏瘫、偏身感觉减退和共济失调。CT和MR成像显示中脑有多叶状海绵状血管瘤。保守治疗后患者几乎无症状,因此未讨论神经外科治疗。后来她的症状有波动,但6个月后她突然出现进行性右侧偏瘫、右侧面部无力、严重吞咽困难和情感失禁,并伴有持续的痉挛性抽泣。对照MRI显示海绵状血管瘤增大并有新的渗血。遂行手术切除海绵状血管瘤。左后颅窝、小脑上入路显示中脑中央有一个充血的海绵状血管瘤,几乎将中脑分开。切除了海绵状血管瘤及伴随的血肿。术后患者的神经症状迅速改善,吞咽困难及运动无力消失。术后6天,我们让一名神经症状消失且能自理的患者出院。文献及所报道的病例表明,正确的时机和恰当的手术可使脑干海绵状血管瘤得以安全切除或显著减轻,从而使神经症状大量缓解。