对pectenotoxin 2的合成研究。第一部分。立体控制合成C10 - C22片段。
Synthetic studies toward pectenotoxin 2. Part I. Stereocontrolled access to the C10-C22 fragment.
作者信息
Aho Jatta E, Salomäki Elina, Rissanen Kari, Pihko Petri M
机构信息
Department of Chemistry, Helsinki University of Technology, POB 6100, FI-02015 TKK, Finland.
出版信息
Org Lett. 2008 Oct 2;10(19):4179-82. doi: 10.1021/ol8015868. Epub 2008 Sep 3.
PMID:18763802
Abstract
A highly stereocontrolled and efficient synthesis for a fully functionalized C 10-C 22 fragment of pectenotoxin 2 is described using a convergent sequence involving a stereoselective methylation of beta-hydroxyketone as a key step.
摘要
描述了一种用于制备pectenotoxin 2的完全官能化C10 - C22片段的高度立体控制且高效的合成方法，该方法采用了一种汇聚式合成路线，其中β - 羟基酮的立体选择性甲基化作为关键步骤。
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