Castner Joanna E, Copland David A, Silburn Peter A, Coyne Terry J, Sinclair Felicity, Chenery Helen J
Centre for Research into Language Processing and Linguistics, Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia.
J Int Neuropsychol Soc. 2008 Sep;14(5):890-4. doi: 10.1017/S1355617708081046.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in individuals with Parkinson's disease (PD) has often been associated with reduced verbal fluency performance. This study aimed to directly assess semantic switching as a function of STN stimulation in PD participants with the Homophone Meaning Generation Test (HMGT). Seventeen participants with PD who had received STN DBS completed the HMGT in on and off stimulation conditions. Twenty-one non-neurologically impaired participants acted as controls. PD participants (in both on and off stimulation conditions) generated significantly fewer meanings than control participants and consistent with the previous reports of verbal fluency impairment, PD participants produced fewer definitions in the on stimulation condition. PD participants (in both on and off stimulation conditions) also had greater difficulty generating definitions for nonhomographic homophones compared with homographic homographs. The results of this study indicate that STN stimulation exacerbates impairment in semantic switching.
对帕金森病（PD）患者的丘脑底核（STN）进行深部脑刺激（DBS）常常与言语流畅性表现下降有关。本研究旨在通过同音异形词意义生成测试（HMGT）直接评估语义转换作为STN刺激对PD参与者的一项功能。17名接受STN DBS的PD参与者在刺激开启和关闭条件下完成了HMGT。21名无神经功能障碍的参与者作为对照。PD参与者（在刺激开启和关闭条件下）生成的意义显著少于对照参与者，并且与先前关于言语流畅性受损的报告一致，PD参与者在刺激开启条件下给出的定义更少。与同形同音异义词相比，PD参与者（在刺激开启和关闭条件下）为非同形同音异义词生成定义也更困难。本研究结果表明，STN刺激会加剧语义转换障碍。
