用2-脱氧-D-半乳糖处理的大鼠吗啡耐受性增强。

Enhanced development of morphine tolerance in rats treated with 2-deoxy-D-galactose.

作者信息

Richter P, Pohle W, Grecksch G, Smalla K H, Jork R, Matthies H

机构信息

Institute of Neurobiology and Brain Research, Magdeburg, Federal Republic of Germany.

出版信息

Psychopharmacology (Berl). 1991;104(2):279-83. doi: 10.1007/BF02244192.

DOI:10.1007/BF02244192

PMID:1876672

Abstract

Rats treated subcutaneously for 6 days with morphine developed a weak tolerance which was characterized by a decrease in the analgesic action of the opioid. Under those experimental conditions a simultaneous intracerebroventricular application of 2-deoxy-D-galactose enhanced development of morphine tolerance, while other deoxy-sugars like 2-deoxy-D-glucose and 6-deoxy-D-galactose were ineffective. In contrast, no influence of 2-deoxy-D-galactose on a more enhanced morphine tolerance after a 11-day pretreatment with morphine was found. The results are discussed in the light of a rather specific interference of 2-deoxy-D-galactose with neuronal glycoprotein processing and related cellular mechanism underlying adaptive processes involved in the development of morphine tolerance.

摘要

用吗啡皮下注射处理6天的大鼠产生了微弱的耐受性，其特征为阿片类药物的镇痛作用减弱。在这些实验条件下，同时脑室内注射2-脱氧-D-半乳糖可增强吗啡耐受性的发展，而其他脱氧糖如2-脱氧-D-葡萄糖和6-脱氧-D-半乳糖则无效。相比之下，未发现2-脱氧-D-半乳糖对吗啡预处理11天后更强的吗啡耐受性有影响。根据2-脱氧-D-半乳糖对神经元糖蛋白加工以及吗啡耐受性发展过程中涉及的适应性过程的相关细胞机制的相当特异性的干扰来讨论这些结果。