缺指（趾）-外胚层发育不良-腭裂综合征中蒸发型干眼的管理
Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome.
作者信息
Ota Yu, Matsumoto Yukihiro, Dogru Murat, Goto Eiki, Uchino Yuichi, Endo Koji, Tsubota Kazuo
机构信息
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
出版信息
Optom Vis Sci. 2008 Sep;85(9):E795-801. doi: 10.1097/OPX.0b013e31818527cd.
PURPOSE
The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome.
CASE REPORT
A single observational case report of a 22-year-old Japanese male with evaporative dry eye and corneal epithelial disease because of lipid layer abnormality resulting from meibomian gland agenesis was treated successfully with low dose lipid base ointment application.
DISCUSSION
The clinical features of the dry eye and ocular surface disease and management issues are discussed.
CONCLUSION
Low dose lipid base ointment application may be a promising treatment modality for the ocular surface disease in ectrodactyly-ectodermal dysplasia (EEC)-clefting syndrome, which seems to help in alleviating the subjective complaints and in improving the objective clinical findings.
目的
本研究旨在报告一例罕见的缺指（趾）-外胚层发育不良-腭裂（EEC）综合征患者的干眼及眼表疾病特征。
病例报告
对一名22岁日本男性进行了单例观察病例报告，该患者因睑板腺发育不全导致脂质层异常，患有蒸发型干眼和角膜上皮疾病，应用低剂量脂质基眼膏成功治疗。
讨论
对干眼及眼表疾病的临床特征和治疗问题进行了讨论。
结论
低剂量脂质基眼膏应用可能是治疗缺指（趾）-外胚层发育不良（EEC）-腭裂综合征眼表疾病的一种有前景的治疗方式，似乎有助于缓解主观症状并改善客观临床体征。
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