减少癌症研究中的偏倚：倾向得分匹配的应用
Reducing bias in cancer research: application of propensity score matching.
作者信息
Reeve Bryce B, Smith Ashley Wilder, Arora Neeraj K, Hays Ron D
机构信息
National Cancer Institute (NCI), Bethesda, MD 20892-7344, USA.
出版信息
Health Care Financ Rev. 2008 Summer;29(4):69-80.
Abstract
In cancer observational studies, differences between groups on confounding variables may have a significant effect on results when examining health outcomes. This study demonstrates the utility of propensity score matching to balance a non-cancer and cancer cohort of older adults on multiple relevant covariates. This approach matches cases to controls on a single indicator, the propensity score, rather than multiple variables. Results indicated that propensity score matching is an efficient and useful way to create a matched case-control study out of a large cohort study, and allows confidence in the strength of the observed outcomes of the study.
摘要
在癌症观察性研究中，在检查健康结果时，混杂变量上的组间差异可能会对结果产生重大影响。本研究证明了倾向得分匹配在平衡老年人非癌症和癌症队列的多个相关协变量方面的效用。这种方法根据单一指标（倾向得分）而非多个变量将病例与对照进行匹配。结果表明，倾向得分匹配是从大型队列研究中创建匹配病例对照研究的一种有效且有用的方法，并能让人对研究观察结果的强度充满信心。
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