一项针对无心血管疾病病史的糖尿病患者使用阿托伐他汀或辛伐他汀治疗的心血管结局的大型观察性研究。
A large observational study of cardiovascular outcomes associated with atorvastatin or simvastatin therapy in diabetic patients without prior cardiovascular disease.
作者信息
Foody Joanne M, Joyce Amie T, Jeffers Barrett W, Liu Larry Z, Benner Joshua S
机构信息
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02130, USA.
出版信息
Diabetes Res Clin Pract. 2008 Oct;82(1):e13-5. doi: 10.1016/j.diabres.2008.07.019. Epub 2008 Sep 6.
Abstract
Analysis of claims data from 46,076 diabetic patients without cardiovascular disease initiating atorvastatin or simvastatin therapy suggested that, after adjusting for demographic and clinical confounders, use of atorvastatin was associated with fewer cardiovascular events versus simvastatin at doses of similar potency (HR 0.88, 95% CI 0.80-0.97, P=0.01).
摘要
对46076名未患心血管疾病且开始使用阿托伐他汀或辛伐他汀治疗的糖尿病患者的索赔数据进行分析表明，在对人口统计学和临床混杂因素进行调整后，在效力相似的剂量下，与辛伐他汀相比，使用阿托伐他汀与较少的心血管事件相关（风险比0.88，95%置信区间0.80-0.97，P=0.01）。
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