3'-C-甲基嘧啶核苷的一些衍生物的合成
Synthesis of some derivatives of 3'-C-methyl pyrimidine nucleosides.
作者信息
Aljarah Mohamed, Mathé Christophe, Périgaud Christian
机构信息
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM 1-UM 2, Université Montpellier 2, case courrier 1705, Place E. Bataillon, 34095 Montpellier cedex 05, France.
出版信息
Nucleic Acids Symp Ser (Oxf). 2008(52):547-8. doi: 10.1093/nass/nrn277.
Attempts for the synthesis of 2'-deoxy-2'-fluoro nucleoside derivative of 3'-C-methyluridine were reported. The corresponding parent nucleoside was chosen as the starting material. However, the 2'-deoxy-2'-fluoro nucleoside was not obtained. Nevertheless, the new and unexpected nucleoside derivatives obtained as well as some proposals of mechanism regarding their formation will be presented.
有报道尝试合成3'-C-甲基尿苷的2'-脱氧-2'-氟核苷衍生物。选用相应的母体核苷作为起始原料。然而，并未得到2'-脱氧-2'-氟核苷。尽管如此，仍将介绍所获得的新型意外核苷衍生物以及关于其形成的一些机理推测。
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