Lauer Thomas, Heiss Christian, Balzer Jan, Keymel Stefanie, Kelm Malte, Preik Michael, Rassaf Tienush
Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany.
Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):677-82. doi: 10.1097/HJR.0b013e32830eb6d8.
Conduit arteries respond to increases in flow by dilating, which is mediated by endothelium-derived nitric oxide. The significance of the interaction between microcirculation and macrocirculation in the flow-mediated dilation (FMD) is poorly understood.
We hypothesize that baseline conduit artery vasomotor tone (CAVT) and resting microvascular resistance (MVR) predict FMD.
We investigated resting diameter and FMD of the brachial artery using high-resolution ultrasound and forearm blood flow with plethysmography in 60 healthy individuals. CAVT was calculated as change of the arterial diameter from baseline to maximal dilation expressed as percentage of the maximum dilation. Resting MVR was determined as quotient of mean arterial blood pressure and forearm blood flow.
Mean FMD was 10.7+/-2.0%, indicating normal endothelial function. The extent of brachial artery FMD was not only related to baseline CAVT (r=0.70, P<0.01), but inversely to resting MVR (r=-0.69, P<0.01). Moreover, in a simple regression analysis, baseline CAVT was inversely related to resting MVR (r=-0.82, P<0.01). In a multivariate linear regression analysis, baseline CAVT and MVR were identified as independent predictors of brachial artery FMD.
Our data imply a close interaction of resting microvascular resistance and baseline CAVT modulating flow-mediated conduit artery dilation.
传导动脉通过扩张对血流量增加做出反应，这是由内皮衍生的一氧化氮介导的。目前对微循环与大循环在血流介导的血管舒张（FMD）中相互作用的意义了解甚少。
我们假设基线传导动脉血管舒缩张力（CAVT）和静息微血管阻力（MVR）可预测FMD。
我们使用高分辨率超声研究了60名健康个体肱动脉的静息直径和FMD，并通过体积描记法测量了前臂血流量。CAVT计算为动脉直径从基线到最大扩张的变化，以最大扩张的百分比表示。静息MVR确定为平均动脉血压与前臂血流量的商。
平均FMD为10.7±2.0%，表明内皮功能正常。肱动脉FMD的程度不仅与基线CAVT相关（r = 0.70，P < 0.01），而且与静息MVR呈负相关（r = -0.69，P < 0.01）。此外，在简单回归分析中，基线CAVT与静息MVR呈负相关（r = -0.82，P < 0.01）。在多元线性回归分析中，基线CAVT和MVR被确定为肱动脉FMD的独立预测因子。
我们的数据表明静息微血管阻力与基线CAVT之间存在密切相互作用，可调节血流介导的传导动脉扩张。
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