Hanus Lumír Ondrej
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Med Res Rev. 2009 Mar;29(2):213-71. doi: 10.1002/med.20135.
Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L. and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp. In addition, details of the pharmacology of natural cannabinoids, as well as synthetic agonists and antagonists are presented. Finally, details regarding the pioneering isolation of the endocannabinoid anandamide, as well as the pharmacology and potential therapeutic uses of endocannabinoid congeners are presented.
对大麻素和内源性大麻素的化学与药理学研究规模巨大，关于大麻（Cannabis sativa L.）和大麻素的文章约有15000篇，关于内源性大麻素的文章超过2000篇。本综述涉及大麻（Cannabis sativa L.）植物的历史、其用途、组成化合物及其生物合成，以及与小舌紫菀属（Radula spp.）化合物的相似性。此外，还介绍了天然大麻素以及合成激动剂和拮抗剂的药理学细节。最后，介绍了内源性大麻素花生四烯乙醇胺的首次分离细节，以及内源性大麻素类似物的药理学和潜在治疗用途。
