Finan Kelly R, Renton David, Vick Catherine C, Hawn Mary T
Section of Gastrointestinal Surgery, Department of Surgery, University of Alabama at Birmingham, KB 417 1530 3rd Ave S, Birmingham, AL 35294, USA.
J Gastrointest Surg. 2009 Feb;13(2):200-5. doi: 10.1007/s11605-008-0687-4. Epub 2008 Sep 10.
Laparoscopic Heller myotomy is the preferred treatment for achalasia. Post-operative leaks cause significant morbidity and impair functional outcome. This study assesses the efficacy of intra-operative leak testing on post-operative leak rate.
A retrospective analysis of 106 consecutive patients undergoing laparoscopic Heller myotomy by a single surgeon between November 2001 and August 2006 was undertaken. Intra-operative leak testing was performed in all patients. Variables associated with intra-operative mucosotomy were assessed by univariate analysis and logistic regression modeling.
Intra-operative mucosotomy occurred in 25% of patients. All mucosotomies were repaired primarily and tested with methylene-blue-stained saline. Dor fundoplication was performed in 74% of the patients. There were no post-operative leaks and patients were started on diet day of surgery. Mean LOS was 1.4(+/-0.7) days. Logistic regression modeling demonstrated that prior myotomy was associated with a statistically significant increase in the rate of mucosotomy (p = 0.033), while previous botox injection (p = 0.193), pneumatic dilation (p = 0.599) or concomitant hiatal hernia (p = 0.874) were not significantly associated with mucosotomy.
Laparoscopic Heller myotomy for the treatment of achalasia is a safe procedure. Intra-operative leak testing minimizes the risk of post-operative leaks and expedites post-operative management. Prior endoscopic treatment does not impair operative results.
腹腔镜下贲门肌层切开术是贲门失弛缓症的首选治疗方法。术后渗漏会导致严重的发病率并影响功能预后。本研究评估术中渗漏检测对术后渗漏率的疗效。
对2001年11月至2006年8月间由同一外科医生连续进行腹腔镜下贲门肌层切开术的106例患者进行回顾性分析。所有患者均进行术中渗漏检测。通过单因素分析和逻辑回归模型评估与术中黏膜切开术相关的变量。
25%的患者发生术中黏膜切开术。所有黏膜切开术均进行了一期修复并用亚甲蓝染色盐水进行检测。74%的患者进行了Dor胃底折叠术。无术后渗漏,患者术后当天开始进食。平均住院时间为1.4(±0.7)天。逻辑回归模型显示,既往肌层切开术与黏膜切开术发生率的统计学显著增加相关(p = 0.033),而既往肉毒杆菌毒素注射(p = 0.193)、气囊扩张(p = 0.599)或合并食管裂孔疝(p = 0.874)与黏膜切开术无显著相关性。
腹腔镜下贲门肌层切开术治疗贲门失弛缓症是一种安全的手术。术中渗漏检测可将术后渗漏风险降至最低,并加快术后管理。既往内镜治疗不影响手术效果。