唑尼沙胺在神经精神疾病中的治疗作用。

Therapeutic role of zonisamide in neuropsychiatric disorders.

作者信息

Farooq Muhammad U, Moore Philip W, Bhatt Archit, Aburashed Rany, Kassab Mounzer Y

机构信息

Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48823, USA.

出版信息

Mini Rev Med Chem. 2008 Sep;8(10):968-75. doi: 10.2174/138955708785740643.

DOI:10.2174/138955708785740643

PMID:18782051

Abstract

Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinson's disease, essential tremor, stroke, obesity, anxiety, bipolar and binge-eating disorders.

摘要

唑尼沙胺（ZNS）是一种磺胺类抗癫痫药物，适用于伴有或不伴有继发性全身性发作的部分性癫痫障碍的辅助治疗。由于其吸收迅速且生物利用度高，唑尼沙胺具有良好的药代动力学特征。其作用与阻断电压门控钠通道和钙通道、调节中枢多巴胺能、γ-氨基丁酸能和5-羟色胺能功能以及抑制碳酸酐酶和单胺氧化酶B有关。唑尼沙胺对一系列神经精神疾病具有潜在疗效，包括偏头痛和其他头痛综合征、神经性疼痛、帕金森病、特发性震颤、中风、肥胖症、焦虑症、双相情感障碍和暴饮暴食症。