来自食鸟蛛属蜘蛛毒液的新型小（4千道尔顿）神经毒素家族。
A new family of small (4kDa) neurotoxins from the venoms of spiders of the genus Phoneutria.
作者信息
Lúcio A D, Campos F V, Richardson M, Cordeiro M N, Mazzoni M S C, de Lima M E, Pimenta M C, Bemquerer M P, Figueiredo S G, Gomes P C, Beirão P S L
机构信息
Dept. of Biochemistry and Immunology; Instituto de Ciências Biológicas, Brazil.
出版信息
Protein Pept Lett. 2008;15(7):700-8. doi: 10.2174/092986608785133708.
A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca(2+) channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.
从巴西游走蛛的毒液中纯化出了一个4千道尔顿的神经毒性肽家族。它们都有六个半胱氨酸残基，与其他神经毒素的相似性较低。三种毒素对L型钙通道有中度抑制作用。对毒素PRTx27C3的结构进行了建模，并与毒素ADO1进行了比较。结果表明了四个残基的重要性。
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