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Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.
Cancer Lett. 2009 Jan 8;273(1):107-13. doi: 10.1016/j.canlet.2008.07.031. Epub 2008 Sep 7.
2
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Mol Cancer Ther. 2009 Apr;8(4):904-13. doi: 10.1158/1535-7163.MCT-08-1050.
8
Anti-tumor compounds identification from gossypol Groebke imidazopyridine product.
Bioorg Chem. 2021 Sep;114:105146. doi: 10.1016/j.bioorg.2021.105146. Epub 2021 Jul 5.

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1
Synthetic, Computational, and Experimental Studies of a Class 3 Atropisomeric α-Naphthyl Tropone.
J Org Chem. 2025 Aug 15;90(32):11501-11509. doi: 10.1021/acs.joc.5c00992. Epub 2025 Aug 5.
2
Studies on the Configurational Stability of Tropolone-Ketone-, Ester-, and Aldehyde-Based Chiral Axes.
J Org Chem. 2024 Jan 5;89(1):541-552. doi: 10.1021/acs.joc.3c02286. Epub 2023 Dec 22.
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Recombinant MDA-7/IL24 Suppresses Prostate Cancer Bone Metastasis through Downregulation of the Akt/Mcl-1 Pathway.
Mol Cancer Ther. 2018 Sep;17(9):1951-1960. doi: 10.1158/1535-7163.MCT-17-1002. Epub 2018 Jun 22.
4
Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo.
Mol Med Rep. 2015 Jun;11(6):4142-8. doi: 10.3892/mmr.2015.3326. Epub 2015 Feb 10.
5
Bcl-2 antagonists: a proof of concept for CLL therapy.
Invest New Drugs. 2013 Oct;31(5):1384-94. doi: 10.1007/s10637-013-0002-4. Epub 2013 Aug 2.
6
Synthesis of benzyl substituted naphthalenes from benzylidene tetralones.
Tetrahedron Lett. 2012 Jan 25;53(4):373-376. doi: 10.1016/j.tetlet.2011.11.065.
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Synthesis of Hemigossypol and its Derivatives.
Tetrahedron Lett. 2010 Oct 3;51(44):5757-5760. doi: 10.1016/j.tetlet.2010.08.089. Epub 2010 Aug 30.
9
An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins.
Front Oncol. 2011 Sep 30;1:28. doi: 10.3389/fonc.2011.00028. eCollection 2011.

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2
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
J Med Chem. 2006 Oct 19;49(21):6139-42. doi: 10.1021/jm060460o.
3
Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS.
J Pharm Biomed Anal. 2006 Nov 16;42(5):581-6. doi: 10.1016/j.jpba.2006.05.020. Epub 2006 Jul 21.
6
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Biochem Pharmacol. 2003 Jul 1;66(1):93-103. doi: 10.1016/s0006-2952(03)00248-x.
7
Apoptosis-based therapies.
Nat Rev Drug Discov. 2002 Feb;1(2):111-21. doi: 10.1038/nrd726.
8
Different pathways of cell killing by gossypol enantiomers.
Exp Biol Med (Maywood). 2002 Jun;227(6):398-401. doi: 10.1177/153537020222700605.
9
Apoptosis: a link between cancer genetics and chemotherapy.
Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6.

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