转化生长因子-β在硬皮病中的促纤维化与抗纤维化作用
Pro- and anti-fibrotic effects of TGF-beta in scleroderma.
作者信息
Sgonc R, Wick G
机构信息
Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Medical University of Innsbruck, Peter-Mayr-Strasse 4a, A-6020 Innsbruck, Austria.
出版信息
Rheumatology (Oxford). 2008 Oct;47 Suppl 5(Suppl 5):v5-7. doi: 10.1093/rheumatology/ken275.
Abstract
The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-beta1) and anti-fibrotic (TGF-beta2 and -beta3) TGF-beta isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.
摘要
加利福尼亚大学戴维斯分校的200和206系（UCD - 200/206）鸡已被证明是最能反映人类系统性硬化症情况的动物模型。我们已经证明促纤维化（转化生长因子β1）和抗纤维化（转化生长因子β2和β3）转化生长因子β亚型失衡可能是该模型纤维化改变的原因。这为这种仍然难以治疗的疾病的诊断和治疗开辟了新途径。
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