Pukrittayakamee Sasithon, Imwong Mallika, Singhasivanon Pratap, Stepniewska Kasia, Day Nicholas J, White Nicholas J
Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Am J Trop Med Hyg. 2008 Sep;79(3):378-84.
The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2-504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/microL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax.
在349例间日疟成年患者中评估了8种抗疟方案和8种含抗生素方案的配子体杀灭及无性阶段活性。63%的患者发现有配子体血症（治疗前22%，治疗后41%）。配子体清除时间中位数（范围）为24小时（范围为2 - 504小时），且与无性疟原虫清除时间相关（r = 0.52，P < 0.001）。间日疟患者中，入院时寄生虫血症>10,000/微升以及接受抗疟活性较弱药物治疗后的患者，配子体血症更为常见，且还与间日疟复发率增加相关（29.4%对14.1%，P = 0.002）。对于所有测试方案，有性阶段活性与无性阶段活性相对应。使用强效抗疟药物治疗可降低间日疟的传播潜能。
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