δ-氨基乙酰丙酸脱水酶多态性与铅负荷对认知功能的相互作用：退伍军人事务部规范老化研究
Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study.
作者信息
Rajan Pradeep, Kelsey Karl T, Schwartz Joel D, Bellinger David C, Weuve Jennifer, Spiro Avron, Sparrow David, Smith Thomas J, Nie Huiling, Weisskopf Marc G, Hu Howard, Wright Robert O
机构信息
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
出版信息
J Occup Environ Med. 2008 Sep;50(9):1053-61. doi: 10.1097/JOM.0b013e3181792463.
OBJECTIVE
We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men.
METHODS
Information on ALAD genotype, lead measurements, potential confounders, and cognitive testing was collected from 982 participants. For each cognitive test and lead biomarker, we fit separate multiple linear regression models, which included an interaction term for ALAD genotype and the lead biomarker and adjusted for potential confounders.
RESULTS
With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers (P interaction = 0.03). However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests.
CONCLUSIONS
The results provide some evidence that ALAD genotype may modify the relation between lead and cognition among older men with low lead burden. However, future work in this area is needed to confirm these suggestive findings.
目的
我们评估了δ-氨基乙酰丙酸脱水酶（ALAD）基因多态性对老年男性铅负荷与认知之间关系的修饰作用。
方法
收集了982名参与者的ALAD基因型、铅测量值、潜在混杂因素及认知测试信息。对于每项认知测试和铅生物标志物，我们拟合了单独的多元线性回归模型，其中包括ALAD基因型与铅生物标志物的交互项，并对潜在混杂因素进行了调整。
结果
与携带ALAD 1-1基因型者相比，携带ALAD 1-2/2-2基因型者在胫骨铅水平较高时，在空间复制测试中的表现更差（P交互作用 = 0.03）。然而，在其他测试中，未发现ALAD基因型与铅之间存在一致的交互作用模式。
结论
结果提供了一些证据，表明ALAD基因型可能会改变低铅负荷老年男性中铅与认知之间的关系。然而，该领域未来的研究需要证实这些提示性发现。
Zotero 插件