Cooper Glinda S, Wither Joan, McKenzie Tamara, Claudio Jaime O, Bernatsky Sasha, Fortin Paul R
United States Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460, USA.
J Rheumatol. 2008 Oct;35(10):2001-4. Epub 2008 Sep 1.
To determine the prevalence and confirmation rate of autoimmune diseases reported by relatives of patients with lupus and controls.
Medical histories were obtained by self-report from 626 first-degree relatives of lupus patients and 267 population controls.
Of 178 reports of an autoimmune disease, 44% were confirmed by medical records; excluding those whose medical records were unavailable, the confirmation rate was 76%. The prevalence of at least one confirmed autoimmune disease was 12% in lupus relatives and 2% in controls.
Methods to improve the reliability of self-reported autoimmune disease history could enhance population and clinic-based research.
确定狼疮患者亲属和对照者报告的自身免疫性疾病的患病率及确诊率。
通过自我报告获取了626名狼疮患者的一级亲属和267名人群对照的病史。
在178份自身免疫性疾病报告中，44%经病历证实；排除病历不可用者后，确诊率为76%。狼疮亲属中至少有一种确诊自身免疫性疾病的患病率为12%，对照者中为2%。
提高自我报告的自身免疫性疾病病史可靠性的方法可加强基于人群和临床的研究。
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