大鼠血浆的差异质谱分析揭示了对17β-雌二醇和选择性雌激素受体调节剂PPT有反应的蛋白质。
Differential mass spectrometry of rat plasma reveals proteins that are responsive to 17beta-estradiol and a selective estrogen receptor modulator PPT.
作者信息
Zhao Xuemei, Deyanova Ekaterina G, Lubbers Laura S, Zafian Pete, Li Jenny J, Liaw Andy, Song Qinghua, Du Yi, Settlage Robert E, Hickey Gerry J, Yates Nathan A, Hendrickson Ronald C
机构信息
Department of Proteomics, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
出版信息
J Proteome Res. 2008 Oct;7(10):4373-83. doi: 10.1021/pr800309z. Epub 2008 Sep 12.
Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) alpha and beta. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17beta-estradiol (E2) or an ERalpha-selective agonist PPT by differential mass spectrometry. Our comparative proteomic experiment identifies novel E2- and PPT-responsive proteins, such as serine protease inhibitor family members.
雌激素是一类甾体激素，可与两种相关但不同的核受体——雌激素受体（ER）α和β相互作用。为了鉴定潜在的ER生物标志物，我们通过差异质谱分析了用赋形剂或17β-雌二醇（E2）或ERα选择性激动剂PPT处理后的大鼠血浆糖蛋白组。我们的比较蛋白质组学实验鉴定出了新的E2和PPT反应蛋白，如丝氨酸蛋白酶抑制剂家族成员。
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