发育、再生和癌症中的黑素细胞。

Melanocytes in development, regeneration, and cancer.

作者信息

White Richard Mark, Zon Leonard I

机构信息

Dana Farber Cancer Institute, Department of Medical Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Stem Cell. 2008 Sep 11;3(3):242-52. doi: 10.1016/j.stem.2008.08.005.

DOI:10.1016/j.stem.2008.08.005

PMID:18786412

Abstract

The genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.

摘要

胚胎发育过程中干细胞特化和谱系限制所需的基因在成体组织再生和癌症中也发挥着重要作用。脊椎动物色素沉着系统就是这种“发育-再生-癌症”轴的例证。在诸如哺乳动物毛发重新着色和斑马鱼鳍再生等再生过程中，黑素细胞表现出几乎无限的自我更新能力。黑色素瘤利用了个体发育和再生过程中所需的许多调控信号和途径。对这些相互联系的讨论突出了在胚胎和再生环境中对干细胞功能的研究如何能够深入了解黑色素瘤生物学。